This work was aimed at developing controlled release amoxicillin trihydrate (MOX) mucoadhesive microspheres to reduce adverse effects, to enhance therapeutic efficacy and to avoid development of resistance for gastric infections. Chitosan, a cationic polymer was selected as and sodium carboxymethyl cellulose (Na CMC), an anionic polymer was selected for mucoadhesion and sustained release respectively. The preparation of microspheres was carried out using ionic gelation method. The prepared microspheres were evaluated for their morphology (shape & size), percentage drug entrapment, in vitro drug release studies and mucoadhesion test on excised stomach mucosa of an albino rat. Prepared microspheres were sphericalin shape with particle size of 30 – 50 m. The percent drug entrapment was found to be around 20%. release profile followed zero order kinetic with around 20 % constant drug release per hour up to 5 hours. Mucoadhesion test suggest microspheres were adhesive to rat stomach mucosa. Therefore, it is safely concluded that mucoadhesive controlled release microspheres of amoxicillin were successfully developed and can be used for optimum delivery of MOX either for local gastric infections or for systemic drug delivery.
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